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CLASSIC Articles

Felitti VJ, Anda RF, et al. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study.  Am J Prev Med. 1998

“The ACES Study:”  Landmark article reignited study of adverse child experiences (ACEs):  emotional, physical, or sexual abuse; neglect; domestic violence; household substance abuse, mentally illness or incarceration.  Demonstrated high prevalence of ACEs and dose-response relationship to physical &mental illness, early death.

Teicher MH and Samson JA.  Enduring neurobiological effects of childhood abuse and neglect.  J Child Psychol Psychiatry, 2016.  FREE FULL TEXT ARTICLE

Highlights:  Neuroimaging of child brains finds maltreatment changes brain development and structure.  Parental verbal abuse, witnessing violence and sexual abuse target brain regions and pathways that process aversive experience.  Structural and functional abnormalities attributed to psychiatric illness may be direct consequence of abuse.

Anda RF, Felitti VJ, Bremner JD, et al. The enduring effects of abuse and related adverse experiences in childhood. Eur Arch Psychiatry Clin Neurosci. 2006  FREE FULL TEXT ARTICLE

Highlights:  Overview of science of toxic stress, development of neuroendocrine-immune network, how function is altered by early life adversity, and how thIs increases vulnerability to disease.  Describes challenges and opportunities for preventing toxic stress in contemporary pediatric practice.

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Jiminez ME,  Adverse Experience in Early Childhood and Kindergarten Outcomes.  Pediatrics 2016.  FREE FULL TEXT.

Danese, A, Moffitt TE, Harrington H et al.  Adverse Childhood Experiences and Adult Risk Factors for Age-Related Disease: Depression, Inflammation, and Clustering of Metabolic Risk Markers.  Arch Pediatr Adolesc Med. 2009.  FREE FULL TEXT ARTICLE

NEW Articles

Turner HA,  Gun Violence Exposure and Posttraumatic Symptoms among Children and Youth J Trauma Stress.  2019.
Survey of 630 US children (age 2-17 years) demonstrated strong association of witnessing gun violence or hearing gunshots with posttraumatic symptoms – although not a direct victim.

Theall KP, Shirtcliff EA, Dismukes AR, et al.  Association between neighborhood violence and biological stress in children.  JAMA Pediatr. 2017  FREE FULL TEXT ARTICLE.
To study association between neighborhood violence and biological stress, a study of 85 black children was conducted.  Increased liquor/convenience stores, domestic violence, and crime were significantly associated with decrease in mean telomere length, and sustained cortisol levels.


Muzik M, et al.  Family Social Support Modifies the Relationships Between Childhood Maltreatment Severity, Economic Adversity and Postpartum Depressive Symptoms.  Matern Child Health J. 2017  FREE FULL TEXT ARTICLE.
First study to demonstrate interrelationships between income and social support on resilience to postpartum depressive symptoms (PDS) in childhood trauma-surviving women.


Fong K.  Child welfare involvement and contexts of poverty: The role of parental adversities, social networks, and social services.  Children and Youth Services Review 2017

Interviews with parents investigated for child maltreatment revealed  adversities related to poverty; embeddedness in disadvantaged networks or volatile personal relationships; and need for social services.  Suggest need to broadly strengthen supports for families and communities.

CLASSIC Articles

Slack K, et al.   Introduction to the special issue on the economic causes and consequences of child maltreatment.  Children and Youth Services Review 2017  FREE FULL TEXT      In depth exploration of correlation of child maltreatment and community- or state-level poverty rates.


Moffitt T  Childhood exposure to violence and lifelong health:  Clinical intervention science and stress biology research join forces.  Dev Psychopath.  2013  FREE FULL TEXT
Evidence of stress-sensitive measures of children exposed to violence (inflammatory reactions, telomere erosion, epigenetic methylation, gene expression, neuroimaging, neuropsychological testing) and identified promising interventions.


Giovanelli A, et al. Adverse childhood experiences and adult well-being in a low-income, urban cohort. Pediatrics. 2016.  FREE FREE TEXT ARTICLE.
1,202 low-income, minority participants in Chicago Longitudinal Study. Those with 4 or more ACEs had significantly reduced likelihood of high school graduation and increased risk for depression, health compromising behaviors, juvenile arrest, and felony charges.

NEW Articles

Chamberlain C,  Parenting after a history of childhood maltreatment:  a scoping review and map of evidence in the perinatal period.  PLOS1 2019.  FREE FULL TEXT
Comprehensive review by the Australian research group HEALING THE PAST BY NURTURING THE FUTURE.  Study found no specific perinatal interventions for parents with childhood maltreatment histories.
but did find interventions which address parental history with positive effects on wellbeing.  Article includes 22 assessment tools for identifying parent childhood maltreatment or impact.


NEW Articles

Dale SK, Weber K, Cohen MH, Brody LR.  Abuse, nocturnal stress hormones, and coronary heart disease risk among women with HIV.  AIDS Care.  2017.

Higher norepinephrine/cortisol ratio was significantly related to higher Coronary Heart Disease (CHD) risk.  Recent sexual abuse, physical abuse, and domestic abuse were significantly related to higher CHD risk.  This association may involve dysregulation of multiple neurobiological systems.​

Rubin LH, …Weber KM, Cohen MH, Martin, EM, et al.  Perceived and post-traumatic stress are associated with decreased learning, memory and fluency in HIV-infected women.  AIDS 2017.

In the context of HIV, stress and PTSD were negatively associated with performance in learning, memory and fluency.  Stress and PTS symptoms are treatment targets to potentially improve cognitive performance particularly when HIV treatment is not optimal.​

NEW Articles

Goldstein E.  Patient preferences for discussing childhood trauma in primary care.  Perm J.  2017   FREE FULL TEXT ARTICLE
​Patient preferences for discussing traumatic experiences and PTSD with clinicians:  most patients agreed they were comfortable being asked about trauma and did not oppose the inclusion of trauma-related information in their medical record.

CLASSIC Articles

Wade R, Shea JA, Rubin D, et al. Adverse childhood experiences of low-income urban youth.  Pediatrics. 2014.  FREE FULL TEXT ARTICLE.
Survey of young adults from low-income urban areas identified experiences not included in the initial ACEs including single-parent homes; exposure to violence, adult themes, and criminal behavior; personal victimization; bullying; economic hardship; and discrimination.


Weinreb L, et al.  Screening for childhood trauma in adult primary care patients: a cross-sectional survey. Prim Care Companion J Clin Psychiatry. 2010.  FREE FULL TEXT ARTICLE
Describes practices, skills, attitudes, and perceived barriers of family physicians in screening adult patients for childhood sexual or physical abuse.  Confidence in screening, perceived role, and knowledge of trauma prevalence were associated with routine and targeted screening.

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Kerker BD, Storfer-Isser A, Szilagyi M, et al. Do pediatricians ask about adverse childhood experiences in pediatric primary care?  Acad Pediatr. 2016.  FREE FULL TEXT ARTICLE

Glowa PT, Olson AL, Johnson DJScreening for adverse childhood experiences in a family medicine setting: a feasibility study.  J Am Board Fam Med2016.  FREE FULL TEXT ARTICLE 

NEW Articles

Leitch L.  Action steps using ACEs and trauma-informed care: a resilience model.  Health Justice.  2017   FREE FULL TEXT ARTICLE

COMMENT:  The ACES study on ACEs and resulting implementation of Trauma-Informed Care (TIC).  Recommends TIC should move from gathering ACEs Data to neuroscience-based action  with practical skills of self-regulation and self-care in both service providers and clients.