ACEs - Adverse Childhood Experiences

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Felitti VJ, Anda RF, et al. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study.  Am J Prev Med. 1998

“The ACES Study:”  Landmark article reignited study of adverse child experiences (ACEs):  emotional, physical, or sexual abuse; neglect; domestic violence; household substance abuse, mentally illness or incarceration.  Demonstrated high prevalence of ACEs and dose-response relationship to physical &mental illness, early death.

Teicher MH and Samson JA.  Enduring neurobiological effects of childhood abuse and neglect.  J Child Psychol Psychiatry, 2016.  FREE FULL TEXT ARTICLE

Neuroimaging of child brains finds that maltreatment changes brain development and structure.  Parental verbal abuse, witnessing violence and sexual abuse target brain regions and pathways that process aversive experience.  Structural and functional abnormalities attributed to psychiatric illness may be direct consequence of abuse.

Anda RF, Felitti VJ, Bremner JD, et al. The enduring effects of abuse and related adverse experiences in childhood. Eur Arch Psychiatry Clin Neurosci. 2006  FREE FULL TEXT ARTICLE

Overview of science of toxic stress, development of neuroendocrine-immune network, how function is altered by early life adversity, and how thIs increases vulnerability to disease. Challenges and opportunities for preventing toxic stress in contemporary pediatric practice.

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Danese, A, Moffitt TE, Harrington H et al.  Adverse Childhood Experiences and Adult Risk Factors for Age-Related Disease: Depression, Inflammation, and Clustering of Metabolic Risk Markers.  Arch Pediatr Adolesc Med. 2009.  FREE FULL TEXT ARTICLE